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To the extent that additional medicinal products containing baclofen (oral) are currently authorised in the EU or are subject to future authorisation procedures in the intrathecal baclofen risks lioresal fibromialgia lioresal intrathecal refill kit 8566 lioresal cp EU, the CMDh recommends that such marketing authorisations are varied accordingly .
Amendments to the product information of the nationally authorised medicinal product(s) Amendments to be included lioresal in the relevant sections of the Product Information (new text underlined and in bold, deleted text strike through) Summary of Product Characteristics A warning should be revised as follows: Abrupt withdrawal: “Treatment should always, (unless serious adverse effects occur), be gradually discontinued by successively reducing the dosage over a period of about 1-2 weeks .
Anxiety and confusional state, delirium, hallucinations, psychotic disorder, mania or paranoia, convulsion (status epilepticus), dyskinesia, tachycardia, hyperthermia, rhabdomyolysis and temporary aggravation of spasticity as a rebound phenomenon have been reported with abrupt withdrawal of Lioresal, especially after long term A warning should be revised as follows: Renal impairment: “Baclofen should be used with caution in patients with renal impairment and should be administered lioresal to end stage renal failure patients only if the expected benefit outweighs the potential risk (See section 4 . 2 Posology and method lioresal of administration) .
Neurological signs and symptoms of overdose lioresal including clinical manifestations of toxic encephalopathy (e .
lioresal remedio lioresal overdose lioresal malaysia lioresal upustvo lioresal y embarazo confusion, disorientation, somnolence and depressed level of consciousness) have been observed in patients with renal impairment taking oral baclofen at doses of more than 5mg per day .

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