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Zopiclone suppressed barbital withdrawal zopiclone signs in rhesus monkeys and, in crab-eating monkeys treated with the drug for several weeks, elicited a withdrawal syndrome upon discontinuation of the drug described to be less severe than with diazepam but similar to nitrazepam (Yanagita, 1983) .
Cross-tolerance with benzodiazepines was demonstrated in an experiment in which zopiclone rats were administered triazolam for two weeks via osmotic minipumps: this treatment caused a reduction of the sedative effect of zopiclone (Cohen and Sanger, 1994) .
Zopiclone was found to produce tolerance in a test developed to assess benzodiazepine receptor-related physical dependence in mice: administration of flumazenil precipitated withdrawal as expressed in reduced electroshock-induced seizure thresholds in animals treated imovane z alkoholem zopiclone is used for zopiklon hangover stilnoct memory loss zopiklon grapefrukt with a high dose of zopiclone for three days (von Voigtlander and Lewis, 1991) .
A most reliable preclinical predictor of abuse of zopiclone copd dopareel autotrader zopiklon mylan bivirkninger dopareel auto stilnoct zwangerschap a psychoactive compound in humans is self-administration of this substance in animals .
zopiclone There is limited evidence regarding self-administration of hypnotics compared to many other drugs of abuse, but self-administration of benzodiazepines can be demonstrated in monkeys .
Self-administration of zolpidem imovane doses buy zopiclone online united pharmacies zopiclone flying stilnoct pris stilnoct has also been demonstrated by Griffiths et al .
(1992) in a study on baboons: one or two weeks zopiclone names stilnoct gravid taking zimovane while pregnant stilnox ulotka zopiklon merck of self-administration of the drug caused tolerance to its sedative and ataxic effects, and withdrawal symptoms upon cessation of the substance .

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