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Take the missed dose as soon as you remember about it. If it is almost time of your next dose just skip it and return to your regular schedule.
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Long-term treatment with Premarin may increase risk of breast cancer, endometrial hyperplasia, heart attack, or stroke so monitoring of the patient's state should be done on a regular basis. This medication can be harmful to an unborn baby, do not use it during pregnancy. Do not use Premarin to prevent hart disease or dementia. To avoid endometrial hyperplasia you may be prescribed to take a progestin together with Premarin. Do not use this drug if you are under 18 y.o..
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Estrogens stimulate the liver's ability to produce factors that promote the clotting of blood. Thus, concomitant administration of Premarin and warfarin (blood thinner) may cause decrease their effects. Barbiturates, Rifampin (Rifadin), phenytoin (Dilantin), carbamazepine (Tegretol), griseofulvin (Grifulvin), St. John's wort and primidone increase metabolism of estrogens. Erythromycin, ketoconazole (Nizoral), itraconazole (Sporanox), and ritonavir (Norvir) act oppositely.
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